HLA-B27 and its role in the pathogenesis of psoriatic arthritis

The literature review presents the characteristics of human leukocyte antigen (HLA)-B27 as a factor contributing to development psoriatic arthritis. HLA-B27 is class I surface encoded by major histocompatibility complex (MHC) B locus located on chromosome 6. main function present antigenic peptides CD8+ T-cells. most important genetic biomarker for arthritis, it provides phenotypic differentiation in patient population. prevalence HLA-B*27 various population groups are presented. structural features molecule described. methods detecting status and determining its subtypes given. mechanisms polymorphism influence arthritis considered, hypotheses analyzed that explain pathogenic effect HLA-B*27: arthritogenic peptide hypothesis, misfolding heavy chain homodimer formation hypothesis. clinical manifestations course HLA-B*27-positive presented, allowing use predict joint damage.